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胎儿自身免疫与共生细菌识别有关

2020-07-18 18:48      点击:

本期文章:《科学》:Volume 369 Issue 6501

美国耶鲁大学Eric Meffre研究组取得一项新突破。他们提出天然人类胎儿B细胞中的自身反应性与共生细菌识别有关。相关论文于2020年7月17日发表在《科学》杂志上。

为了研究这种明显的悖论,他们评估了从人类胎儿肝脏、骨髓和脾脏的单个B细胞克隆的450多种抗体的反应性。他们发现早期人类胎儿生命中不完全的B细胞耐受性有利于多反应性B细胞的积累,该多反应性B细胞结合了健康成年人的凋亡细胞和共生细菌。

因此,限制性的胎儿免疫前库包含潜在的有益的自反应性先天样B细胞特异性,可促进发育过程中凋亡细胞的去除,以及出生后肠道菌群的组装。

据悉,假定胎儿发育过程中受限制的V(D)J重组可限制抗体库的范围并防止自身免疫。 但是,新生儿血清中含有丰富的自身抗体,这表明妊娠过程中对B细胞的耐受性尚未完全确立。

附:英文原文

Title: Autoreactivity in nave human fetal B cells is associated with commensal bacteria recognition

Author: Jeff W. Chen, Tyler A. Rice, Jason M. Bannock, Agata A. Bielecka, Juliet D. Strauss, Jason R. Catanzaro, Haowei Wang, Laurence C. Menard, Jennifer H. Anolik, Noah W. Palm, Eric Meffre

Issue&Volume: 2020/07/17

Abstract: Restricted V(D)J recombination during fetal development was postulated to limit antibody repertoire breadth and prevent autoimmunity. However, newborn serum contains abundant autoantibodies, suggesting that B cell tolerance during gestation is not yet fully established. To investigate this apparent paradox, we evaluated the reactivities of more than 450 antibodies cloned from single B cells from human fetal liver, bone marrow, and spleen. We found that incomplete B cell tolerance in early human fetal life favored the accumulation of polyreactive B cells that bound both apoptotic cells and commensal bacteria from healthy adults. Thus, the restricted fetal preimmune repertoire contains potentially beneficial self-reactive innate-like B cell specificities that may facilitate the removal of apoptotic cells during development and shape gut microbiota assembly after birth.

DOI: 10.1126/science.aay9733

Source: https://science.sciencemag.org/content/369/6501/320

期刊信息

Science:《科学》,创刊于1880年。隶属于美国科学促进会,最新IF:41.037

官方网址:https://www.sciencemag.org/

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